Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?
نویسندگان
چکیده
منابع مشابه
INTRODUCTION TO ENDOCRINE DISRUPTING CHEMICALS (EDCs) A GUIDE FOR PUBLIC INTEREST ORGANIZATIONS AND POLICY-MAKERS
ii Founded in 1916, the Endocrine Society is the world's oldest, largest, and most active organization devoted to research on hormones and the clinical practice of endocrinology. The Endocrine Society's membership consists of over 18,000 scientists, physicians, educators, nurses, and students in more than 100 countries. Society members represent all basic, applied and clinical interests in endo...
متن کاملDifferential Activation of a Mouse Estrogen Receptor β Isoform (mERβ2) with Endocrine-Disrupting Chemicals (EDCs)
BACKGROUND Endocrine-disrupting chemicals (EDCs) are suspected of altering estrogenic signaling through estrogen receptor (ER) α or β (mERβ1 in mice). Several EDC effects have been reported in animal studies and extrapolated to human studies. Unlike humans, rodents express a novel isoform of ERβ (mERβ2) with a modified ligand-binding domain sequence. EDC activity through this isoform remains un...
متن کاملRemoval of endocrine disrupting chemicals (EDCs) using low pressure reverse osmosis membrane (LPROM).
Endocrine disrupting chemicals (EDCs) are the focus of current environmental issues, as they can cause adverse health effects to animals and human, subsequent to endocrine function. The objective of this study was to remove a specific compound of EDCs (i.e. pentachlorophenol, C(6)OCL(5)Na, molecular weight of 288 g/mol) using low pressure reverse osmosis membrane (LPROM). A cross flow module of...
متن کاملAssessing dose–response relationships for endocrine disrupting chemicals (EDCs): a focus on non-monotonicity
The fundamental principle in regulatory toxicology is that all chemicals are toxic and that the severity of effect is proportional to the exposure level. An ancillary assumption is that there are no effects at exposures below the lowest observed adverse effect level (LOAEL), either because no effects exist or because they are not statistically resolvable, implying that they would not be adverse...
متن کاملIn Vivo Testing System for Determining the Estrogenic Activity of Endocrine- Disrupting Chemicals (EDCs) in Goldfish (Carassius auratus)
Graduate School of Science and Technology, Environmental Protection center, and Faculty of Environmental Studies, Nagasaki University, 1–14 Bunkyo-machi, Nagasaki 852–8521, Japan, Department of Chemical and Biological Engineering, Ariake National College of Technology, 150 Higashihagiomachi, Omuta 836–8585, Japan, and Faculty of Environmental and Symbiotic Sciences, Prefectural University of Ku...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Archives of Toxicology
سال: 2020
ISSN: 0340-5761,1432-0738
DOI: 10.1007/s00204-020-02800-8